Covid 19 Drug Interactions

Covid 19 remains a problem. From the cardiology perspective, the main issue now is the use of anti-virals and drug interactions.

Paxlovid (nirmatrelvir/ritonavir) is the main drug of concern with respect to drug interactions. Unfortunately, there has been numerous incidents of drug interaction resulting in harm.

Commonly used cardiac drugs that are absolute contraindications to Paxlovid include (but not limited to)

  • Amiodarone, dronedarone

  • Flecainide

  • Propafenone

  • Ivabradine

  • Bosnian, Sildenafil, Tadalafil

Here are two great tools to check drug interactions. It is best to double check for each individual patient.

University of Liverpool Covid 19 Drug Interactions

University of Waterloo School of Pharmacy